WebOct 24, 2024 · We discovered that Cu is required for the activity of the autophagic kinases ULK1/2 through a direct Cu-ULK1/2 interaction. Genetic loss of the Cu transporter … WebJul 14, 2010 · The studies described in this report suggest that cisplatin-induced ototoxicity and cochlear uptake can be modulated by administration of a CTR1 inhibitor, copper …
The copper transporter Ctr1 contributes to cisplatin uptake by
WebCTR1 phosphorylates the C-terminal domain of EIN2, preventing its nuclear translocation that activates downstream ethylene signaling. Without ethylene, EIN2 is constantly targeted for the ubiquitin proteasome–dependent degradation pathway ( 15 – 19 ). WebThe possibility of local administration of CTR1 inhibitors during cisplatin therapy as a means of otoprotection is thereby raised. AB - The goal of this study was to determine the role of an influx copper transporter, CTR1, in the ototoxicity induced by cisplatin, a potent anticancer platinum analog used in the treatment of a variety of solid ... gps wilhelmshaven personalabteilung
Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes
WebThe copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. The usefulness and efficacy of cisplatin, a chemotherapeutic … WebNov 9, 2015 · Cisplatin-induced ototoxicity and cochlear uptake can be modulated by administration of a CTR1 inhibitor, copper sulfate, and the possibility of local administration of CTR1 inhibitors during cisplatin therapy as a … WebJul 12, 2024 · PDF Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as... Find, read and cite all the research you need on ... gps wilhelmshaven