Sin3b cancer

Author: tmue

August undefined, 2024

WebbHuman hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth leading cause of cancer-related death worldwide, and the incidence of HCC has been on the rise in recent decades. [ 1 , 2 ] Current treatment options include liver transplantation or surgical resection, while first-line chemotherapeutic agents include sorafenib, lenvatinib, … WebbCancer type Any Bile duct cancer Bladder cancer Bone cancer Brain cancer Breast cancer Cervical cancer Colorectal cancer Esophageal cancer Gallbladder cancer Gastric cancer Head and neck cancer Kidney cancer Leukemia Liver cancer Lung cancer Lymphoma Myeloma Neuroblastoma Non-cancerous Ovarian cancer Pancreatic cancer Prostate …

SIN3B - Antibodies - The Human Protein Atlas

WebbCANCER ATLAS. Gene description. SIN3 transcription regulator family member B: Protein class. Predicted intracellular proteins: Protein evidence. Evidence at protein level WebbExpression of SIN3B (KIAA0700) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability … can ear infection increase blood pressure

Abstract A15: Sin3B: a non-classical tumor suppressor

Webb13 aug. 2012 · We show that Sin3A is downregulated in a variety of human tumors and that Src, JNK, RhoA and PP1B/β-Catenin are regulated in a manner analogous to our … Webb1 jan. 2016 · Sin3B also interacts with an E3 ubiquitin ligase, RNF220 that targets Sin3B for ubiquitination and promotes its proteasomal degradation (Kong et al., 2010). Recently … Webb8 aug. 2014 · In leukemia cells and fibroblasts, Sin3b silencing led to Myc up-regulation, whereas Sin3b overexpression induced Myc deacetylation and degradation. An analysis of Sin3b expression in breast tumors revealed an association between low Sin3b expression and disease progression. can ear infection cause neck pain headache

Sin3B: An essential regulator of chromatin modifications

SIN3B (SIN3 transcription regulator family member B)

WebbWe previously demonstrated that the histone deacetylase-associated protein SIN3B is essential for oncogene-induced senescence in cultured cells. Here, using a mouse model … Webb29 aug. 2024 · This finding reveals a largely unexplored function for Sin3b in the nervous system. Sin3 is not essential for viability in S. cerevisiae (Sternberg et al., 1987) but Drosophila sin3 and murine Sin3a and Sin3b mutants are lethal (Pennetta and Pauli, 1998; Cowley et al., 2005; Dannenberg et al., 2005; David et al., 2008; Sharma et al., 2008 ). fisichiWebb17 apr. 2024 · SIN3 is a global transcriptional coregulator that governs expression of a large repertoire of gene targets. It is an important player in gene regulation, which can repress or activate diverse gene targets in a context-dependent manner. can ear infection clear on its own

"WebbSIN3B TISSUE CELL PATHOLOGY PATHOLOGY ATLAS GENE/PROTEIN ANTIBODIES AND VALIDATION Dictionary PROGNOSTIC SUMMARYi Prognostic marker in prostate cancer … " - Sin3b cancer

Sin3b cancer

SIN3B (SIN3 transcription regulator family member B)

Webb12 aug. 2009 · Importantly, expression of Sin3B increases upon oncogenic stress, both in vitro and in vivo, correlating with the induction of the senescence program, but is … WebbExpression of SIN3B (KIAA0700) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability …

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Webb1 nov. 2016 · In pancreatic cancer, Sin3B was found to promote cancer progression by senescence-associated inflammation . Although these studies provide clear evidence for the involvement of SIN3 complexes in cancer, it is not understood how or under what context SIN3 complexes favor suppressive or promoting functions for tumor progression. WebbExpression of SIN3B (KIAA0700) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of our website. If you continue, we'll assume that you …

Webb1 okt. 2024 · SIN3B has been implicated in the initiation of senescence in vitro. Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant … Webb1kla, 1klc, 1kld, 3kfd, 네임스페이스. 기사; 토론

WebbSIN3B. The antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays through which the antibody has been validated. Assays&annotation provide a detailed description of the different assays. The pie-charts indicate degree of validation. Webb9 apr. 2024 · Innovate through Integrated Solutions Home; Contact Us; English Deutsch; 日本語; 简体中文; Products. Product Browser; Product Discounts & Benefits

Webb1 jan. 2016 · Sin3A/B are global transcription regulators that provide a versatile platform for diverse chromatin-modifying activities. Sin3 proteins regulate key cellular functions that include cell cycle, proliferation, and differentiation, and have recently been implicated in cancer pathogenesis. can ear infection make you sickWebb1 juli 2008 · These observations strongly suggest that Sin3B plays an essential role in coordinating the chromatin modifying activities required for the transient repression of pro-proliferation genes in... fisico david bohmWebb29 nov. 2016 · SIN3 corepressor complexes play important roles in both normal development and breast cancer. Mammalian cells have two paralogs of SIN3 (SIN3A … can ear infection heal without antibioticsWebbSIN3B. The antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays … fisics monistesWebb8 aug. 2014 · As Sin3b is also required for transcriptional repression by Mxd-Max complexes, our results suggest that, at least in some cell types, Sin3b limits Myc activity … can ear infections affect your eyesWebb14 aug. 2024 · Oncomine expression analysis using two independent studies showed that SIN3B is significantly downregulated in carcinoma compared to normal prostate tissue, and that SIN3B lies among the top 10% most downregulated transcripts in prostate cancer (ranked 1,384 out of 22,238 genes and 83 out of 8,603 genes, respectively) (Fig. 6A, B). fisico keplerWebb29 sep. 2014 · While Sin3B is dispensable for cell survival and proliferation in primary fibroblasts, it is required for entry into quiescence upon serum withdrawal, and for entry into cellular senescence... fisicully